![]() monandra is effective as an antidote for treating HIT. The results from this study show that leaf methanolic extract of B. Acute toxicity test showed no significant physical and behavioral changes. It also significantly decreased the bleeding and clotting time. 2 It is specifically used in heparin overdose, in low molecular weight heparin overdose, and to reverse the effects of heparin during delivery and heart surgery. wt had significantly (P < 0.05) higher platelet counts (225.10 ± 6.41) than the control groups: normal control (181.90 ± 11.38) and positive control (127.65 ± 5.79). Protamine sulfate is a medication that is used to reverse the effects of heparin. ![]() This study showed that the mice in the group treated with methanolic leaf extract of B. ![]() Bleeding time and clotting time were also determined. It is used when quick reversal of the action of heparin is needed as in case of bleeding or after an open heart surgery. Furthermore, blood samples were collected to determine the blood platelet count. Abstract: Heparin antidote is protamine sulphate. monandra at a dose of 100, 200, and 400 mg/kg body weight (b. Groups III, IV, and V (treatment groups) were given heparin and methanolic leaf extract of B. PS has toxic side effects and limitations. To date, protamine sulphate (PS), a cationic polypeptide is the only clinically approved antidote for unfractionated heparin. Antidotes are administered to counteract anticoagulation and to restore normal hemostasis. Group I (normal control) was given distilled water only, and Group II (positive control) was given heparin only. Haemorrhage in surgical patients receiving anticoagulants is a major concern. The mice were divided into five Groups (I–V) of six mice each. A total of 30 mice were used for the experimental study. The aim of the study was to determine the effect of methanolic leaf extract of Bauhinia monandra as a potential antidote for treating heparin-induced thrombocytopenia (HIT). Currently, chemical compounds for managing thrombocytopenia are needed. ![]() Globally, thrombocytopenic cases in hospitals leading to 80% of deaths are mainly due to refractory bleeding and lack of availability of platelet concentrates. Thrombocytopenia is closely associated with heparin therapy and hematological disorders and other common diseases in patients admitted in the hospital. ![]()
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